(S, R, S) -AHPC-Me
Product Specifications
CAS Number
1948273-02-6
Target
Ligand for E3 Ligase
Related Pathways
PROTAC
Purity
0.9986
Bioactivity
(S, R, S) -AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is an (S, R, S) -AHPC-based VHL ligand used to recruit the von Hippel-Lindau (VHL) protein. It is utilized in the synthesis of ARV-771, a VHL E3 ligase-based BET PROTAC degrader that effectively degrades BET proteins in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
Smiles
C([C@H](C(C)(C)C)N)(=O)N1[C@H](C(N[C@@H](C)C2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
Molecular Formula
C23H32N4O3S
Molecular Weight
444.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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