RGB-286638 (free base)
RGB-286638 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.
Product Specifications
CAS Number
784210-88-4
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
CDK; GSK-3; JAK; MEK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/RGB-286638-free-base.html
Purity
98.87
Solubility
DMSO : 2.6 mg/mL (ultrasonic) |Ethanol : < 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NN1CCOCC1)NC2=CC=CC(C3=C4C(C5=CC=C(CN6CCN(CCOC)CC6)C=C5)=NN3)=C2C4=O
Molecular Formula
C29H35N7O4
Molecular Weight
545.63
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
CDK1; CDK2; CDK3; CDK4; CDK5; CDK6; CDK7; CDK9; GSK-3β; JAK2; MEK1
Citation 01
Cancers (Basel) . 2022 Mar 19;14 (6) :1575.|Science. 2017 Dec 1;358 (6367) :eaan4368.|University of Washington. 2025.
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