AMG-47a

Product Specifications

CAS Number

882663-88-9

Target

Kras|||Ras|||JAK|||VEGFR|||p38 MAPK|||Src

Related Pathways

Chromatin/Epigenetic|||MAPK|||Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling|||Stem Cells

Purity

0.9807

Bioactivity

AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.

Smiles

Cc1ccc(cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F

Molecular Formula

C29H28F3N5O2

Molecular Weight

535.56

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

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