AMG-47a
Product Specifications
CAS Number
882663-88-9
Target
Kras|||Ras|||JAK|||VEGFR|||p38 MAPK|||Src
Related Pathways
Chromatin/Epigenetic|||MAPK|||Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling|||Stem Cells
Purity
0.9807
Bioactivity
AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.
Smiles
Cc1ccc(cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F
Molecular Formula
C29H28F3N5O2
Molecular Weight
535.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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