Pitavastatin
Product Specifications
CAS Number
147511-69-1
Target
Autophagy, Mitophagy, HMG-CoA Reductase, Apoptosis
Related Pathways
Autophagy, Apoptosis, Metabolism
Purity
0.9717
Bioactivity
Pitavastatin (NK-104) is a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase, effectively inhibiting cholesterol synthesis from acetic acid in HepG2 cells with an IC50 of 5.8 nM. It also induces hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptors and exhibits therapeutic activities such as anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective, and reno-protective effects.
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C(=C/[C@H](C[C@H](CC(O)=O)O)O)\C1=C(C2=C(N=C1C3CC3)C=CC=C2)C4=CC=C(F)C=C4
Molecular Formula
C25H24FNO4
Molecular Weight
421.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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