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Shogaol

Product Specifications

CAS Number

555-66-8

Target

Autophagy, Lipoxygenase

Related Pathways

Metabolism, Autophagy

Purity

0.9993

Bioactivity

1. 6-Shogaol (6-Shogaol) has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory property, reduces the inflammatory response and protected the femoral cartilage from damage produced in a CFA monoarthritic model of the knee joint of rats. 3. 6-Shogaol inhibits the growth of human cancer cells and induces apoptosis in COLO 25 cells through modulation of mitochondrial functions regulated by reactive oxygen species (ROS) . 4. 6-Shogaol effectively inhibit invasion and metastasis of hepatocellular carcinoma through diverse molecular mechanisms, including inhibition of the MAPK and PI3k/Akt pathways and NF-κB and STAT3 activities to suppress expression of MMP-2/-9 and uPA and block angiogenesis, could further regulate urokinase-type plasminogen activity.

Smiles

CCCCC\C=C\C(=O)CCc1ccc(O)c(OC)c1

Molecular Formula

C17H24O3

Molecular Weight

276.37

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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