Linarin
Product Specifications
CAS Number
480-36-4
Target
PKA|||Apoptosis|||Cholinesterase (ChE) |||HIV Protease|||Influenza Virus|||Antibacterial|||TNF
Related Pathways
Proteases/Proteasome|||Tyrosine Kinase/Adaptors|||Neuroscience|||Microbiology/Virology|||Apoptosis
Purity
0.9899
Bioactivity
1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-?-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-?-mediated apoptotic pathways. 3. Linarin prevents A beta-induced neurotoxicity through the activation of PI3K/Akt, which subsequently inhibits GSK-3b and up-regulates Bcl-2. 4. The piperine significantly enhanced the oral absorption of Linarin in rats by inhibiting P-glycoprotein mediated cellular efflux during the intestinal absorption and likely simultaneously by inhibiting the metabolism of Linarin.
Smiles
COc1ccc(cc1)-c1cc(=O)c2c(O)cc(OC3OC(COC4OC(C)C(O)C(O)C4O)C(O)C(O)C3O)cc2o1
Molecular Formula
C28H32O14
Molecular Weight
592.55
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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