Linarin

Product Specifications

CAS Number

480-36-4

Target

PKA|||Apoptosis|||Cholinesterase (ChE) |||HIV Protease|||Influenza Virus|||Antibacterial|||TNF

Related Pathways

Proteases/Proteasome|||Tyrosine Kinase/Adaptors|||Neuroscience|||Microbiology/Virology|||Apoptosis

Purity

0.9899

Bioactivity

1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-?-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-?-mediated apoptotic pathways. 3. Linarin prevents A beta-induced neurotoxicity through the activation of PI3K/Akt, which subsequently inhibits GSK-3b and up-regulates Bcl-2. 4. The piperine significantly enhanced the oral absorption of Linarin in rats by inhibiting P-glycoprotein mediated cellular efflux during the intestinal absorption and likely simultaneously by inhibiting the metabolism of Linarin.