Picropodophyllin
Product Specifications
CAS Number
477-47-4
Target
Apoptosis, IGF-1R
Related Pathways
Tyrosine Kinase/Adaptors, Apoptosis
Purity
0.9983
Bioactivity
Picropodophyllin (Picropodophyllin (PPP) ) (PPP) is a specific IGF-1R inhibitor (IC50: 1 nM) . Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT) .
Smiles
[H][C@]12COC(=O)[C@@]1([H])[C@H](c1cc(OC)c(OC)c(OC)c1)c1cc3OCOc3cc1[C@@H]2O
Molecular Formula
C22H22O8
Molecular Weight
414.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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