Pexmetinib
Product Specifications
CAS Number
945614-12-0
Target
P38 MAPK, Autophagy, Tie-2
Related Pathways
Autophagy, MAPK, Tyrosine Kinase/Adaptors
Purity
0.9966
Bioactivity
Pexmetinib (ARRY-614) is an orally bioavailable dual p38 MAPK/Tie-2 inhibitor studied in acute myeloid leukemia and inhibits osteoclastogenesis and breast cancer-induced osteolysis via the P38/STAT3 signaling pathway.
Smiles
Cc1ccc(cc1)-n1nc(cc1NC(=O)NCc1cc(F)ccc1Oc1ccc2n(CCO)ncc2c1)C(C)(C)C
Molecular Formula
C31H33FN6O3
Molecular Weight
556.63
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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