Quisinostat dihydrochloride
Product Specifications
CAS Number
875320-31-3
Target
Apoptosis, Autophagy, HDAC
Related Pathways
Chromatin/Epigenetic, Autophagy, DNA Damage/DNA Repair, Apoptosis
Purity
0.985
Bioactivity
Quisinostat dihydrochloride (JNJ26854165 (Quisinostat) 2HCl) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2.
Smiles
Cl.Cl.Cn1cc(CNCC2CCN(CC2)c2ncc(cn2)C(=O)NO)c2ccccc12
Molecular Formula
C21H28Cl2N6O2
Molecular Weight
467.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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