Flavopiridol
Product Specifications
CAS Number
146426-40-6
Target
Autophagy, HIV Protease, Apoptosis, CDK
Related Pathways
Cell Cycle/Checkpoint, Autophagy, Proteases/Proteasome, Apoptosis, Microbiology/Virology
Purity
0.9999
Bioactivity
Flavopiridol (Alvocidib) (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, 4, 6 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Phase 1/2.
Smiles
CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl
Molecular Formula
C21H20ClNO5
Molecular Weight
401.84
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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