Xevinapant
Product Specifications
CAS Number
1071992-99-8
Target
Apoptosis, IAP
Related Pathways
Apoptosis
Purity
0.9994
Bioactivity
Xevinapant (Debio-1143) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1.
Smiles
CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)CC(C)C
Molecular Formula
C32H43N5O4
Molecular Weight
561.71
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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