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Bafilomycin A1

Product Specifications

CAS Number

88899-55-2

Target

Autophagy|||Apoptosis|||Proton pump|||Antibiotic|||Antibacterial

Related Pathways

Microbiology/Virology|||Autophagy|||Membrane transporter/Ion channel|||Apoptosis

Purity

0.9936

Bioactivity

Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase inhibitor (IC50=0.44 nM) that is specific and reversible. Bafilomycin A1 is an inhibitor of the late phase of autophagy, blocking the fusion of autophagosomes with lysosomes. Bafilomycin A1 also induces apoptosis.

Smiles

[H][C@@]1(OC(=O)\C(OC)=C\C(\C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C\C(C)=C\C=C\[C@@H]1OC)[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O)[C@H](C)[C@H](O1)C(C)C

Molecular Formula

C35H58O9

Molecular Weight

622.83

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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