WYE-687
Product Specifications
CAS Number
1062161-90-3
Target
Src, PI3K, p38 MAPK, mTOR
Related Pathways
MAPK, Angiogenesis, PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors
Purity
0.9993
Bioactivity
WYE-687 is an ATP-competitive and selective inhibitor of mTOR with an IC50 of 7 nM; it blocks mTORC1/pS6K (T389) and mTORC2/P-AKT (S473) without affecting P-AKT (T308) . Its selectivity for mTOR is greater than PI3Kα (>100-fold) and PI3Kγ (>500-fold) .
Smiles
COC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4cccnc4)CC3)c2n1
Molecular Formula
C28H32N8O3
Molecular Weight
528.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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