WYE-354
Product Specifications
CAS Number
1062169-56-5
Target
PI3K, Apoptosis, mTOR, Autophagy
Related Pathways
Apoptosis, PI3K/Akt/mTOR signaling, Autophagy
Purity
0.9961
Bioactivity
WYE-354 (IC50=5 nM) is an effective, selective and ATP-competitive mTOR inhibitor. It blocks mTORC2/P-AKT (S473) and mTORC1/P-S6K (T389), not P-AKT (T308) . The selectivity for mTOR is higher than PI3Kα (>100-fold) and PI3Kγ (>500-fold) .
Smiles
COC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)OC)c2n1
Molecular Formula
C24H29N7O5
Molecular Weight
495.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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