TAME
Product Specifications
CAS Number
901-47-3
Target
APC/C
Related Pathways
Cell Cycle/Checkpoint
Bioactivity
TAME (Tosyl-Arginine Methyl Este), an inhibitor of the late-promoting complex (APC/C or APC), inhibits APC-dependent protein hydrolysis by competing for APC binding with the C-terminal isoleucine-arginine tail of the APC activator cytokinesis cycle 20 (Cdc20) . TAME binds to and prevents APC binding by Cdc20 and Cdh20. TAME binds to APC and prevents its activation by Cdc20 and Cdh1.
Smiles
S(N[C@@H](CCCNC(=N)N)C(OC)=O)(=O)(=O)C1=CC=C(C)C=C1
Molecular Formula
C14H22N4O4S
Molecular Weight
342.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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