Ro 31-8220
Product Specifications
CAS Number
125314-64-9
Target
JNK, Others, PKC
Related Pathways
MAPK, Cytoskeletal Signaling, Chromatin/Epigenetic, Others
Bioactivity
Ro 31-8220 is a potent inhibitor of PKC with IC50 values of 5, 24, 14, 27, 24, and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε, and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1, and GSK3β with IC50 values of 3, 8, 15, and 38 nM, respectively, without affecting MKK3, MKK4, MKK6, and MKK7.
Smiles
O=C1C(C=2C=3C(N(CCCSC(=N)N)C2)=CC=CC3)=C(C(=O)N1)C=4C=5C(N(C)C4)=CC=CC5
Molecular Formula
C25H23N5O2S
Molecular Weight
457.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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