NSC697923
Product Specifications
CAS Number
343351-67-7
Target
Apoptosis|||E1/E2/E3 Enzyme
Related Pathways
Apoptosis|||Ubiquitination
Purity
0.9984
Bioactivity
NSC-697923 (2-[ (4-methylphenyl) sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage and NF-?B signaling, further contributing to its antitumor activity.
Smiles
Cc1ccc(cc1)S(=O)(=O)c1ccc(o1)[N+]([O-])=O
Molecular Formula
C11H9NO5S
Molecular Weight
267.26
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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