Indoximod
Product Specifications
CAS Number
110117-83-4
Target
Indoleamine 2,3-Dioxygenase (IDO), IDO
Related Pathways
Metabolism
Purity
0.9955
Bioactivity
Indoximod (NLG-8189) is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2, 3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy.
Smiles
Cn1cc(C[C@@H](N)C(O)=O)c2ccccc12
Molecular Formula
C12H14N2O2
Molecular Weight
218.25
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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