Golvatinib
Product Specifications
CAS Number
928037-13-2
Target
C-Met/HGFR, VEGFR
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis
Purity
0.995
Bioactivity
Golvatinib (E-7050) is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity. c-Met/VEGFR kinase inhibitor E7050 binds to and inhibits the activities of both c-Met and VEGFR-2, which may inhibit tumor cell growth and survival of tumor cells that overexpress these receptor tyrosine kinases. c-Met and VEGFR-2 are upregulated in a variety of tumor cell types and play important roles in tumor cell growth, migration and angiogenesis.
Smiles
CN1CCN(CC1)C1CCN(CC1)C(=O)Nc1cc(Oc2ccc(NC(=O)C3(CC3)C(=O)Nc3ccc(F)cc3)c(F)c2)ccn1
Molecular Formula
C33H37F2N7O4
Molecular Weight
633.69
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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