Dovitinib lactate hydrate
Product Specifications
CAS Number
915769-50-5
Target
VEGFR, FGFR, FLT, c-Kit, PDGFR
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis
Purity
0.9982
Bioactivity
Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. Phase 4.
Smiles
O.CC(O)C(O)=O.CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O
Molecular Formula
C24H27FN6O4
Molecular Weight
482.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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