CYC-116
Product Specifications
CAS Number
693228-63-6
Target
VEGFR, FLT, Aurora Kinase, S6 Kinase, CDK
Related Pathways
MAPK, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, PI3K/Akt/mTOR signaling, Angiogenesis, Cell Cycle/Checkpoint
Purity
0.9759
Bioactivity
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1.
Smiles
Cc1nc(N)sc1-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Molecular Formula
C18H20N6OS
Molecular Weight
368.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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