Clevudine
Product Specifications
CAS Number
163252-36-6
Target
Virus Protease, DNA/RNA Synthesis, HBV
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Microbiology/Virology
Purity
0.9998
Bioactivity
Clevudine (Levovir) is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV) . Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase (reverse transcriptase) . Clevudine has a long half-life and shows significant reduction of covalently closed circular DNA (cccDNA), therefore the patient is less likely to have a relapse after treatment is discontinued.
Smiles
Cc1cn([C@H]2O[C@@H](CO)[C@H](O)[C@H]2F)c(=O)[nH]c1=O
Molecular Formula
C10H13FN2O5
Molecular Weight
260.22
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K4499207 1.0 µg DNA
Mthfd1l sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)
Sign In for Pricing
View Details 
IRBAMLTPSAB1AP289200UL 200 µL
Rabbit Anti TPSAB1 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (IHC) 200ul
Sign In for Pricing
View Details NBP2-54436IR 100 µL
Mouse Monoclonal Clathrin light chain Antibody (CLC/1421) [DyLight 755]
Sign In for Pricing
View Details