Clevudine
Product Specifications
CAS Number
163252-36-6
Target
Virus Protease|||DNA/RNA Synthesis|||HBV
Related Pathways
DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Microbiology/Virology
Purity
0.9998
Bioactivity
Clevudine (Levovir) is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV) . Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase (reverse transcriptase) . Clevudine has a long half-life and shows significant reduction of covalently closed circular DNA (cccDNA), therefore the patient is less likely to have a relapse after treatment is discontinued.
Smiles
Cc1cn([C@H]2O[C@@H](CO)[C@H](O)[C@H]2F)c(=O)[nH]c1=O
Molecular Formula
C10H13FN2O5
Molecular Weight
260.22
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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