Vimirogant hydrochloride
Product Specifications
Target
Others, ROR
Related Pathways
Metabolism, Others
Bioactivity
Vimirogant (VTP-43742) hydrochloride is an orally active, selective RORγt inhibitor (IC50: 17 nM, Ki: 3.5 nM) that is more than 1000 times more selective than RORα and RORβ. It inhibits Th17 differentiation and IL-17A secretion in mouse spleen cells with an IC50 of 57 nM and does not affect Th1, Th2, or Treg cell differentiation.
Molecular Formula
C27H36ClF3N4O3S
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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