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JAK1/TYK2-IN-3

Product Specifications

Target

Others|||JAK

Related Pathways

Angiogenesis|||Others|||Tyrosine Kinase/Adaptors|||Stem Cells|||Chromatin/Epigenetic|||JAK/STAT signaling

Bioactivity

JAK1/TYK2-IN-3 is a selective, potent, orally active dual inhibitor of TYK2 (IC50: 6 nM) and JAK1 (IC50: 37 nM), with selective action on JAK2 (IC50: 140 nM) and JAK3 (IC50: 362 nM) . It regulates the expression of TYK2/JAK1-related genes and formation of Th1, Th2, and Th17 cells to exert anti-inflammatory activity.

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Product Datasheet

https://www.targetmol.com/attachment/DataSheet/D586A41C-EC76-4398-8815-20617685CCBF/T64265

Available Sizes

Curated Selection

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