JAK1/TYK2-IN-3
Product Specifications
Target
Others|||JAK
Related Pathways
Angiogenesis|||Others|||Tyrosine Kinase/Adaptors|||Stem Cells|||Chromatin/Epigenetic|||JAK/STAT signaling
Bioactivity
JAK1/TYK2-IN-3 is a selective, potent, orally active dual inhibitor of TYK2 (IC50: 6 nM) and JAK1 (IC50: 37 nM), with selective action on JAK2 (IC50: 140 nM) and JAK3 (IC50: 362 nM) . It regulates the expression of TYK2/JAK1-related genes and formation of Th1, Th2, and Th17 cells to exert anti-inflammatory activity.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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