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HDAC/HSP90-IN-4

Product Specifications

Target

Others, HSP, HDAC

Related Pathways

Cytoskeletal Signaling, Metabolism, DNA Damage/DNA Repair, Others, Chromatin/Epigenetic

Bioactivity

HDAC/HSP90-IN-4 significantly inhibited HDAC and HSP90 activity, with compound 20 (HDACIC50= 194 nM; HSP90αIC50= 153 nM) and compound 26 ((HDACIC50= 360 nM; HSP90αIC50= 77 nM) having the strongest HDAC and HSP90α inhibition. effect. Both compounds induced HSP90 expression and down-regulated HSP90 client proteins, which play an important role in the regulation of cancer cell survival and invasion.

Molecular Formula

C20H23N3O6

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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