Tandutinib hydrochloride
Product Specifications
CAS Number
2438900-70-8
Target
FLT, Apoptosis, c-Kit, PDGFR, Others
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, Others, Apoptosis
Bioactivity
Tandutinib hydrochloride (MLN518 hydrochloride) is a potent, selective FLT3 inhibitor with an IC50 of 0.22 μM and also effectively inhibits c-Kit and PDGFR, with IC50 values of 0.17 μM and 0.20 μM, respectively. This compound is clinically applicable for treating acute myelogenous leukemia (AML) and can cross the blood-brain barrier.
Smiles
O(C)C1=CC=2C(=NC=NC2C=C1OCCCN3CCCCC3)N4CCN(C(NC5=CC=C(OC(C)C)C=C5)=O)CC4.Cl
Molecular Formula
C31H43ClN6O4
Molecular Weight
599.16
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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