Sacibertinib
Product Specifications
CAS Number
1351941-69-9
Target
Others, EGFR, Trk receptor
Related Pathways
Others, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis
Bioactivity
Sacibertinib is a tyrosine kinase (Trk) inhibitor with activity against EGFR-TK phosphorylation (EC50: 110 nM) and HER2 (EC50: 244 nM), demonstrating antitumor effects.
Smiles
N(C=1C2=C(C=C(O[C@H]3CCOC3)C(NC(/C=C/CN(C)C)=O)=C2)N=CC1C#N)C4=CC(Cl)=C(OCC5=CC=CC=N5)C=C4
Molecular Formula
C32H31ClN6O4
Molecular Weight
599.08
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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