NXPZ-2
Product Specifications
CAS Number
2254492-08-3
Target
Nrf2, Others
Related Pathways
Others, Immunology/Inflammation
Bioactivity
NXPZ-2 is an orally active Keap1-Nrf2 protein-protein interaction (PPI) inhibitor (Ki: 95 nM, EC50: 120 and 170 nM) . NXPZ-2 dose-dependently attenuates Aβ[1-42]-induced cognitive disturbances, enhances neuronal number and function, and improves pathological alterations in the brain of Alzheimer's disease (AD) mice. NXPZ-2 has potential for studies of Keap1-Nrf2 PPI inhibitors and AD-related disorders.
Smiles
N(S(=O)(=O)C1=CC=C(OC)C=C1)(CC(N)=O)C=2C3=C(C(N(S(=O)(=O)C4=CC=C(N)C=C4)CC(N)=O)=CC2)C=CC=C3
Molecular Formula
C27H27N5O7S2
Molecular Weight
597.66
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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