NU5455
Product Specifications
CAS Number
1257235-99-6
Target
Others, DNA-PK
Related Pathways
Others, PI3K/Akt/mTOR signaling, DNA Damage/DNA Repair
Bioactivity
NU5455 is a selective, potent, orally active inhibitor of DNA-PKcs. It enhances the efficacy of locally released doxorubicin in liver tumor xenografts without causing adverse effects and also enhances the efficacy and toxicity of parenterally administered topoisomerase inhibitors.
Smiles
N(C(CN1CCOCC1)=O)(C)C=2C=C3C=4C(=C(C=CC4)C5=C6C(C(=O)C=C(O6)N7CC8OC(C7)CC8)=CC=C5)SC3=CC2
Molecular Formula
C34H33N3O5S
Molecular Weight
595.71
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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