CX-5461 dihydrochloride
Product Specifications
Target
DNA/RNA Synthesis, Others
Related Pathways
Others, Cell Cycle/Checkpoint, DNA Damage/DNA Repair
Bioactivity
CX-5461 dihydrochloride is a potent, orally active inhibitor of Pol I-mediated rRNA synthesis that acts on HCT-116 cells (IC50: 142 nM), A375 cells (IC50: 113 nM) and MIA PaCa-2 cells (IC50: 54 nM), and to a lesser extent on Pol II (IC50 ≥ 25 μM) .
Molecular Formula
C27H29Cl2N7O2S
Molecular Weight
586.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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