FXR antagonist 1
Product Specifications
CAS Number
2295804-68-9
Target
Others, FXR
Related Pathways
Metabolism, Others
Bioactivity
FXR antagonist 1 is a selective, orally active intestinal FXR antagonist with an IC50 value of 2.1 μM. FXR antagonist 1 antagonises intestinal FXR and selectively inhibits intestinal FXR signalling by feedback activation of hepatic FXR. FXR antagonist 1 can improve liver steatosis, inflammation and fibrosis in the NASH (non-alcoholic steatohepatitis) model and can be used to study NASH.
Smiles
C(NCC(O)=O)(=O)[C@]12[C@@]([C@@]3([C@@](C)(CC1)[C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)(C(C)(C)[C@H](OC(CCC)=O)CC5)[H])[H])[H])([C@H]([C@H](C)C)CC2)[H]
Molecular Formula
C36H59NO5
Molecular Weight
585.86
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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