AChE/GSK-3β-IN-1
Product Specifications
CAS Number
2412364-73-7
Target
Others, Microtubule Associated, ROS Kinase, Cholinesterase (ChE), GSK-3
Related Pathways
Others, Stem Cells, Tyrosine Kinase/Adaptors, PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, Neuroscience
Bioactivity
AChE/GSK-3β-IN-1 is a potent dual AChE/GSK-3β inhibitor that crosses the blood-brain barrier and acts on hAChE (IC50: 1.2 nM), hBChE (IC50: 149.8 nM) and hGSK-3β (IC50: 22.4 nM) . AChE/GSK-3β-IN-1 is able to occupy the ATP binding site of DYRK1A. aChE/GSK-3β-IN-1 exhibits high kinase selectivity for the CMGC kinase family. aChE/GSK-3β-IN-1 inhibits ROS expression and reduces oxidative stress. aChE/GSK-3β-IN-1 can be used to study Alzheimer's disease.
Smiles
N(CCNCC(NC1=CC(=CC=N1)C2=NC(OCC3CC3)=C(C(NC)=O)S2)=O)C4=C5C(=NC=6C4=CC=CC6)CCCC5
Molecular Formula
C31H35N7O3S
Molecular Weight
585.72
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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