Debio 0617B
Product Specifications
CAS Number
1332329-27-7
Target
Others, JAK, STAT, Bcr-Abl
Related Pathways
Others, Chromatin/Epigenetic, Stem Cells, Cytoskeletal Signaling, Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors
Bioactivity
Debio 0617B is a multi-kinase inhibitor that reduces maintenance and self-renewal of primary human AML CD34+ stem/progenitor cells. debio 0617B targets key kinases upstream of STAT3/STAT5 signalling, such as JAK, ABL, SRC and class III/V receptor tyrosine kinases. debio 0617B can be used to study STAT3 driven solid tumours.
Smiles
ClC=1C(N2CC=3C(CC2)=NC(NC4=CC=C(C(NC)=O)C=C4)=NC3)=CC(NC(=O)C5=CC(C(F)(F)F)=CC=N5)=CC1
Molecular Formula
C28H23ClF3N7O2
Molecular Weight
581.98
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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