Regorafenib mesylate
Product Specifications
CAS Number
835621-08-4
Target
Others, c-Kit, PDGFR, c-RET, VEGFR, FGFR, Tie-2, Raf, Autophagy
Related Pathways
Autophagy, Tyrosine Kinase/Adaptors, Others, Angiogenesis, Apoptosis, MAPK
Bioactivity
Regorafenib (BAY 73-4506) mesylate is an orally active multi-target receptor tyrosine kinase inhibitor, inhibiting VEGFR1/2/3 (IC50=13/4.2/46 nM), PDGFRβ (IC50: 22 nM), Kit (IC50: 7 nM), RET (IC50: 1.5 nM), and Raf-1 (IC50: 2.5 nM), with potent anti-tumor and anti-angiogenic effects.
Smiles
CS(O)(=O)=O.CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c(F)c2)ccn1
Molecular Formula
C22H19ClF4N4O6S
Molecular Weight
578.92
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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