GZD856 formic
Product Specifications
CAS Number
2804039-78-7
Target
Apoptosis, PDGFR, Others, Bcr-Abl
Related Pathways
Angiogenesis, Others, Apoptosis, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling
Bioactivity
GZD856 formic is a potent, orally active inhibitor of PDGFRα/β and Bcr-Abl T315I, demonstrating IC50 values of 68.6 nM and 136.6 nM for PDGFRα/β, respectively, and 19.9 nM and 15.4 nM for native Bcr-Abl and the T315I mutant, respectively. This compound exhibits significant antitumor activity.
Smiles
C(O)=O.C(C1=C(C(F)(F)F)C=C(NC(=O)C2=CC(C#CC3=CN4C(N=C3)=CC=N4)=C(C)C=C2)C=C1)N5CCN(C)CC5
Molecular Formula
C30H29F3N6O3
Molecular Weight
578.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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