G12Si-5

Product Specifications

CAS Number

2946593-46-8

Target

Others, Kras, Ras

Related Pathways

MAPK, Others

Bioactivity

G12Si-5 is a covalent inhibitor of the K-RasG12S mutant with a Ki value of 26 μM. It binds to the S-IIP structural domain, inhibiting oncogenic signaling and reducing ERK phosphorylation levels in KRAS G12S mutant cells.

Smiles

C(OC=1N=C(C2=C(N1)C(F)=C(N=C2)C=3C4=C(C=CC3)C=CC=C4Cl)N5C[C@]6([C@@](CC5)(C(=O)O6)[H])[H])C78N(CCC7)CCC8

Molecular Formula

C31H29ClFN5O3

Molecular Weight

574.05

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

More Discoveries

Explore Other Products

Browse additional items from our catalog

MBS1226406-01 0.02 mg (E-Coli)

Recombinant Bacillus anthracis 3-dehydroquinate dehydratase (aroQ)

View Details

MBS1226406-02 0.1 mg (E-Coli)

Recombinant Bacillus anthracis 3-dehydroquinate dehydratase (aroQ)

View Details

MBS1226406-03 0.02 mg (Yeast)

Recombinant Bacillus anthracis 3-dehydroquinate dehydratase (aroQ)

View Details

MBS1226406-04 0.1 mg (Yeast)

Recombinant Bacillus anthracis 3-dehydroquinate dehydratase (aroQ)

View Details

MBS1226406-05 0.02 mg (Baculovirus)

Recombinant Bacillus anthracis 3-dehydroquinate dehydratase (aroQ)

View Details

MBS1226406-06 0.02 mg (Mammalian-Cell)

Recombinant Bacillus anthracis 3-dehydroquinate dehydratase (aroQ)

View Details