G12Si-5
Product Specifications
CAS Number
2946593-46-8
Target
Others, Kras, Ras
Related Pathways
MAPK, Others
Bioactivity
G12Si-5 is a covalent inhibitor of the K-RasG12S mutant with a Ki value of 26 μM. It binds to the S-IIP structural domain, inhibiting oncogenic signaling and reducing ERK phosphorylation levels in KRAS G12S mutant cells.
Smiles
C(OC=1N=C(C2=C(N1)C(F)=C(N=C2)C=3C4=C(C=CC3)C=CC=C4Cl)N5C[C@]6([C@@](CC5)(C(=O)O6)[H])[H])C78N(CCC7)CCC8
Molecular Formula
C31H29ClFN5O3
Molecular Weight
574.05
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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