Keap1-Nrf2-IN-14
Product Specifications
CAS Number
1928782-31-3
Target
Reactive Oxygen Species, Others, Nrf2
Related Pathways
Others, NF-κB, Metabolism, Immunology/Inflammation
Bioactivity
Keap1-Nrf2-IN-14 is a KEAP1-NRF2 inhibitor that effectively disrupts the KEAP1-NRF2 interaction (IC50: 75 nM) with a Kd=24 nM for KEAP1. Keap1-Nrf2-IN-14 induces the expression of NRF2 target genes and is able to enhance downstream antioxidant and anti-inflammatory effects. -Nrf2-IN-14 can be used to study oxidative stress-related inflammation.
Smiles
N(S(=O)(=O)C1=C(C)C=C(C)C=C1C)(CC(O)=O)C=2C3=C(C(OC(C(O)=O)C4=CC=C(OC)C=C4)=CC2)C=CC=C3
Molecular Formula
C30H29NO8S
Molecular Weight
563.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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