IKKβ-IN-1
Product Specifications
CAS Number
2410423-31-1
Target
Others, IκB/IKK
Related Pathways
NF-κB, Others
Bioactivity
IKKβ-IN-1 is a potent, orally active inhibitor of IkappaB (IKK-β) with an IC50 of 0.20 μM. It reduces the inhibition of PGE2 and TNF-α production in murine macrophages and protects mice from infection shock-induced death.
Smiles
O=C\1N(C(=O)S/C1=C\C2=CC=C(OC3=CC=C(C#N)C=C3)C=C2)C4=CC=C(OCCCN5CCN(C)CC5)C=C4
Molecular Formula
C31H30N4O4S
Molecular Weight
554.66
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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