EGFR-IN-62
Product Specifications
Target
Apoptosis, EGFR, Others
Related Pathways
Apoptosis, Others, JAK/STAT signaling, Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
EGFR-IN-62 is a potent inhibitor of EGFR kinase with IC50 values of 10 nM for L858R/T790 M, 29 nM for WT and 2 42 nM for L858R/T790 M/C797S. EGFR-IN-62 blocks the cell cycle of A549 and/or H1975 cells in G1/G0 phase and induces apoptosis and motility inhibition. EGFR-IN-62 effectively inhibited the proliferation of A549 (IC50: 2.53 μM) and H1975 cells (IC50: 1.56 μM) .
Molecular Formula
C30H33N9O2
Molecular Weight
551.64
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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