KRAS G12C inhibitor 47
Product Specifications
CAS Number
2253119-24-1
Target
Others, Ras, Kras
Related Pathways
Others, MAPK, GPCR/G Protein
Bioactivity
KRAS G12C inhibitor 47 is a potent inhibitor of KRAS G12C (IC50: 0.172 μM) . KRAS G12C inhibitor 47 exhibits p-ERK inhibition in MIA PaCA-2 cells, A549 cells with IC50 values of 0.046 μM and 69.8 μM respectively. KRAS G12C inhibitor 47 showed investigational potential against pancreatic, colorectal and lung cancers.
Smiles
O=C1N(C=2C(C(=N1)N3CCN(C(C=C)=O)CC3)=CC(Cl)=C(C2)C4=C(F)C=CC=C4O)C5=C(C(C)C)C=CC=C5
Molecular Formula
C30H28ClFN4O3
Molecular Weight
547.02
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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