CDK9/10/GSK3?-IN-1
Product Specifications
CAS Number
2423045-06-9
Target
Others|||CDK
Related Pathways
Others|||Cell Cycle/Checkpoint
Bioactivity
CDK9/10/GSK3?-IN-1 is a kinase inhibitor (Flavopiridol analogue) that effectively inhibits HsGSK3?, HsCDK9/CyclinT, HsCDK5/p25 and HsCDK2/CyclinA with IC50 values of 59 nM, 64 nM, 1.093 ?M and 1.725 ?M, respectively. CDK9/10/GSK3?-IN-1 exhibited comparable or higher anti-cancer cell activity than Flavopiridol and showed high anti-proliferative activity against up to seven cancer cell lines in vitro.
Smiles
OC=1C(=C2C(C(=O)C=C(O2)C3=C(Cl)C=C(SC=4N(C)C=5C(N4)=CC=CC5)C=C3)=C(O)C1)C=6CCN(C)CC6
Molecular Formula
C29H24ClN3O4S
Molecular Weight
546.04
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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