What is the catalog number for Cort108297?

The catalog number for Cort108297 is HY-15710.

What sizes are available for Cort108297?

Cort108297 is available in the following size(s): 1 mg, 5 mg, 10 mM - 1 mL, 10 mg, 50 mg, 100 mg.

How many pack sizes does Cort108297 come in?

Cort108297 is available in 6 different pack sizes.

Is Cort108297 in stock?

Cort108297 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Cort108297?

Cort108297 is manufactured by QuantiMol.

What is the estimated delivery time for Cort108297?

Estimated delivery time for Cort108297 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Cort108297?

The safety data sheet for Cort108297 is available here: http://file.medchemexpress.com/batch_PDF/HY-15710/Cort108297-SDS-MedChemExpress.pdf.

Cort108297

Cort108297 is a specific glucocorticoid receptor (GR) antagonist. Cort108297 has a high affinity for GRs with a Ki of 0.45 nM.

Product Specifications

CAS Number

1018679-79-2

UNSPSC

12352005

Hazard Statement

H302, H315, H320, H335

Target

Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Cort108297.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(N1C[C@@]2(COCC)CC3=C(N(C4=CC=C(F)C=C4)N=C3)C=C2CC1)(C5=CC=C(C(F)(F)F)C=C5)=O

Molecular Formula

C26H25F4N3O3S

Molecular Weight

535.55

Precautions

H302, H315, H320, H335

References & Citations

[1]Sindelar DK, et al. LLY-2707, a novel nonsteroidal glucocorticoid antagonist that reduces atypical antipsychotic-associated weight gain in rats. J Pharmacol Exp Ther. 2014 Jan;348 (1) :192-201.|[2]Kach J, et al. Selective Glucocorticoid Receptor Modulators (SGRMs) Delay Castrate-Resistant Prostate Cancer Growth. Mol Cancer Ther. 2017 Aug;16 (8) :1680-1692.|[3]Asagami T, et al. Selective Glucocorticoid Receptor (GR-II) Antagonist Reduces Body Weight Gain in Mice. J Nutr Metab. 2011;2011:235389.|[4]Solomon MB, et al. The selective glucocorticoid receptor antagonist CORT 108297 decreases neuroendocrine stress responses and immobility in the forced swim test. Horm Behav. 2014 Apr;65 (4) :363-71.