Safusidenib
Product Specifications
CAS Number
1898206-17-1
Target
Others, Isocitrate Dehydrogenase (IDH)
Related Pathways
Others, Metabolism
Bioactivity
Safusidenib is a selective, orally active mutant inhibitor of IDH1 that significantly inhibits mutant IDH1, but not wild-type IDH1, and inhibits tumor activity in chondrosarcoma. safusidenib is active against IDH1R132H and IDH1R132C, and in the absence of preincubation, the IC50 values were 15 and 130 nM, respectively.
Smiles
C(=O)(C=1C(=NOC1C(C)(C)F)C2=C(Cl)C=C(Cl)C=C2Cl)N3C=4C(C(C)=C3)=C(/C=C/C(O)=O)C=CC4
Molecular Formula
C25H18Cl3FN2O4
Molecular Weight
535.78
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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