EGFR-IN-60
Product Specifications
CAS Number
2699877-43-3
Target
Apoptosis, EGFR, Others
Related Pathways
Apoptosis, JAK/STAT signaling, Angiogenesis, Others, Tyrosine Kinase/Adaptors
Bioactivity
EGFR-IN-60 is an effective, orally active, safe antitumor agent. EGFR-IN-60 significantly inhibits EGFRWT (IC50: 83 nM), EGFRT790M (IC50: 26 nM), EGFRL858R (IC50: 53 nM) and JAK3 (IC50: 69 nM) . IN-60 inhibited H1975 cells carrying the EGFRT790M mutation (IC50: 1.32 μM) and A431 cells overexpressing EGFRWT (IC50: 4.96 μM) . EGFR-IN-60 increased the Bax/Bcl-2 ratio, which induced apoptosis induction and cell death.
Smiles
O=C1C=2C(C3=C(NC2CC(C)(C)C1)N=CN(N=CC4=CC=C(N(C)C)C=C4)C3=N)C5=C(Cl)C(Cl)=CC=C5
Molecular Formula
C28H28Cl2N6O
Molecular Weight
535.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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