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P-gp inhibitor 5

Product Specifications

CAS Number

2451298-06-7

Target

Others, P-gp

Related Pathways

Membrane transporter/Ion channel, Others, Neuroscience

Bioactivity

P-gp inhibitor 5 is a potent P-glycoprotein (P-gp) inhibitor, reducing P-gp activity by a factor of 2.5 and 3.0 at 1.25 μM and 2.5 μM, respectively. It exhibits anti-proliferative effects on certain cancer cells and restores cellular sensitivity to Vincristine and Paclitaxel, reversing the multidrug resistant (MDR) phenotype of ABCB1/Flp-InTM-293 and KBvin.

Smiles

O(C(C)=O)C1=C2C(=C(NC(=O)C3=C(Cl)C=CC=C3)OC2=CC(=C1)C4=CC=C(OC)C=C4)C5=CC=CS5

Molecular Formula

C28H20ClNO5S

Molecular Weight

517.98

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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